Vertex Pharmaceuticals Inc. CEO Reshma Kewalramani first came to the United States at the age of 11. A self-described awkward sixth-grader, she found comfort in two disciplines: math and science.

“You could sit with a piece of paper or a book and really take yourself a long way from where you started,” Kewalramani said. “I just found it to be one of those areas that gave me a lot of joy and solace when needed.”

Now CEO of one of the nation’s largest biopharmaceutical companies (Nasdaq:…

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